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More than 1500 kilometers separate Antofagasta and Santa Cruz, the city can be accessed through Route 5. In order to reach your destination you must travel by stopovers, first passing through Santiago and San Fernando and then reaching Santa Cruz. As it is a stopover trip, you must hire the services of different companies to reach your destination, however some of those that will accompany you during the trip are Buses Nilahue, Turbus and Andimar.
Another option if you are looking for a new way to travel, we bring you the carpooling service, another alternative when you are looking to travel with more comfort.
Kupos.com offers all ground transportation services and a much safer, more comfortable and more reliable way to reserve your ticket. By entering kupos.com, users can book their tickets, plan and choose the means of transport they prefer.
We give you the facility to compare services from different companies so that you can quote and buy in the fastest and easiest way.
Antofagasta is a beautiful city located in the northern part of Chile, in the Atacama Desert. It has a sunny climate throughout the year and is highly visited by tourists, especially during the summer.
It is a city that benefits widely from mining and tourism, places like La Mano del Desierto or the La Portada Monument have made Antofagasta a mystical place full of adventures.
The pleasant climatic conditions allow you to enjoy multiple tourist services, attractive landscapes, shopping centers, beaches with warm waters and gentle waves, and also historical and natural monuments, when visiting the city you cannot miss the Historic District of Antofagasta and the Croatia Park.
Santa Cruz is a city that is located in the O'Higgins Region. The city has a warm climate during the summer and cold with frequent rains in the winter. The mixture of these environmental factors, climate, soil and water have allowed Santa Cruz to consolidate itself as an important agricultural center recognized for the production of wines and for being part of the famous Wine Route.
The city is characterized by its colonial architecture, with buildings from the 19th century, such as the Santa Cruz parish and the Carillon Clock. In your visit to this city you cannot miss a tour of the Colchagua Museum and have a good time at the Colchagua Casino.
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Precio Maximo (CLP): $
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sat, 15 Aug 2026
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In Chile there are bus companies offering regular services from Antofagasta to Santa Cruz.
At kupos.cl we let you compare prices, schedules and services from most bus companies in Chile online. You can visit kupos.cl or download our app and buy your tickets in the easiest and most convenient way for you, using cash, debit or credit card, PayPal, etc. You can also buy your tickets directly on the bus company's website.
The cheapest bus ticket from Antofagasta to Santa Cruz costs CLP$ , and is available on August 14, 2026 at kupos.cl.
offers the cheapest bus ticket from Antofagasta to Santa Cruz, in a seat for CLP $ , to travel on August 14, 2026 at kupos.cl.
The distance between Antofagasta and Santa Cruz is 0 Kms, and the bus trip can take a minimum of 00 hours.
The earliest departure to travel by bus from Antofagasta to Santa Cruz is at and is offered by
The latest departure to travel by bus from Antofagasta to Santa Cruz is at and is offered by .
According to reviews and ratings from kupos.cl users, the three best companies for travelling by bus from Antofagasta to Santa Cruz are:
On buses from Antofagasta to Santa Cruz
Generally, buses travelling from Antofagasta to Santa Cruz have the following features and amenities: phone charger, WiFi, air conditioning, television, coffee, among others.
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