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.png "Transantin"){kind=logo}
184 kilometers away from Santiago is Santa Cruz, you can access the city through Route 5. At kupos.cl we take you to Santa Cruz with Buses Nilahue and MT Bus, you can also travel with the bus company Transantin. Trips to Santa Cruz depart from the Sur Terminal of Santiago.
However, if you are looking for a new way to travel, we bring you the carpooling service, another alternative when you are looking to travel comfortable, safe and for less money.
kupos.cl offers all ground transportation services in a much safer, more comfortable and reliable way, allowing users to reserve their tickets, plan and choose the means of transportation they prefer.
Security is an integral part of our service. At kupos.cl we give you the facility to compare services from different companies so that you can quote and buy in the most timely manner.
Santiago is the center of development of the main economic activities in Chile, it is a cosmopolitan and hectic city, which easily reflects the history and culture of the country through its network of more than 20 museums and cultural centers, in addition, it has several heritage sites and galleries that you can visit during your visit to this city.
It has a pleasant temperate climate and prolonged dry seasons during the year, because of that it rarely rains in Santiago. It is the seventh most populated city in Latin America, being the most populated urban nucleus in the country.
Santa Cruz is a city that is located in the Colchagua Valley, in the O'Higgins Region. The city has a Mediterranean climate, warm in summer and cold with frequent rains in winter. During the rest of the year, the lands receive their water supply from the Tinguiririca River, which flows into Lake Rapel. The union of these environmental factors, climate, soil and water have allowed Santa Cruz to consolidate itself as an important agricultural center recognized for the production of wines and tours of its vineyards.
Cheaper emi-cama 
Cheaper alon-cama 
Cheaper remium 
No Empresas: 4
Precio Maximo (CLP): $ 9.000
Primera Salidas al dia: 06:10:00 hrs
Distancia: 0 Kms
No Servicios: 46
Precio Minimo (CLP): $ 0
Ultima Salida del dia: 20:20 hrs
Duration: 00 HRS
sun, 16 Aug 2026
mon, 17 Aug 2026
tue, 18 Aug 2026
wed, 19 Aug 2026
CLP$ 5.000
CLP$ 5.000
CLP$ 5.000
CLP$ 5.000
Based on 10252 reviews Based on 18763 reviews Based on 437 reviews Based on 7896 reviewsIn Chile there are 4 bus companies offering regular services from Santiago to Santa Cruz.
Transantin, Pullman Bus, Expreso Santa Cruz, Jet Sur
At kupos.cl we let you compare prices, schedules and services from most bus companies in Chile online. You can visit kupos.cl or download our app and buy your tickets in the easiest and most convenient way for you, using cash, debit or credit card, PayPal, etc. You can also buy your tickets directly on the bus company's website.
The cheapest bus ticket from Santiago to Santa Cruz costs CLP$ 0, and is available on August 15, 2026 at kupos.cl.
Transantin offers the cheapest bus ticket from Santiago to Santa Cruz, in a Premium seat for CLP $ 0, to travel on August 15, 2026 at kupos.cl.
The distance between Santiago and Santa Cruz is 0 Kms, and the bus trip can take a minimum of 00 hours.
The earliest departure to travel by bus from Santiago to Santa Cruz is at 06:10:00 and is offered by Transantin
The latest departure to travel by bus from Santiago to Santa Cruz is at 20:20 and is offered by Jet Sur.
According to reviews and ratings from kupos.cl users, the three best companies for travelling by bus from Santiago to Santa Cruz are: Rating Transantin, (3.7* based on 10252 ratings), Rating Pullman Bus, (3.5* based on 18763 ratings), Rating Expreso Santa Cruz, (3.9* based on 437 ratings), Rating Jet Sur, (3.2* based on 7896 ratings),
On buses from Santiago to Santa Cruz a Semi cama seat costs around CLP$6.500, a Salon cama seat costs around CLP$5.400, a Premium seat costs around CLP$0, a Ejecutivo seat costs around CLP$6.400, a Clasico seat costs around CLP$6.400,
Generally, buses travelling from Santiago to Santa Cruz have the following features and amenities: phone charger, WiFi, air conditioning, television, coffee, among others.
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