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The city of Uyuni in Bolivia is located 1958 kilometers away from Santiago and the place can be accessed through land by Route 5.
If you want to travel by bus you will have to travel around 30 hours to reach your destination, first you must take a bus from Santiago to Calama, some of the companies that make this trip are Expreso Norte, Pullman Bus, Ciktur, Turbus and Plusschile that depart from Terminal Alameda and Terminal San Borja. Once you are in Calama, you must take another bus that will take you to Uyuni, you can hire the services of Atacama 2000 or Cruz del Norte that make direct trips from Calama to Uyuni.
Uyuni is located in the Andes Mountains and is a place recognized worldwide for its beauty. At kupos.cl we take you safely and efficiently to your destination, we have ground transportation alternatives, different payment methods and many options to plan your trip in the most convenient way. kupos.cl is the best alternative to get around.
Santiago is the capital city of Chile, it is a large city, in which different cultural mixes are appreciated, it is a city widely visited by tourists and that offers everything you can look for. When visiting its streets you will find various heritage sites, cultural centers and museums. In addition, there are several hills and parks that provide the city with a green lung.
Santiago has a privileged location, being in the central area, it has an excellent connection with the rest of the country. Due to its constant temperate climate, it is ideal to visit it throughout the year, however you must bear in mind that during the winter the average temperature is close to 13ºC, reaching down to 4ºC.
Uyuni is located in the Department of Potosí, in Bolivia. It is an important tourist center in the country and is connected to the main cities through the Joya Andina Airport.
It is the main access road to the Salar de Uyuni which is the largest continuous salt desert in the world and was named in 2019 as the best tourist destination in the world according to CNN.
Other places of tourist interest are the train cemetery, the clock located in the center of the city and the Stone Tree.
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Precio Maximo (CLP): $
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sun, 16 Aug 2026
mon, 17 Aug 2026
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In Chile there are bus companies offering regular services from Santiago to Uyuni.
At kupos.cl we let you compare prices, schedules and services from most bus companies in Chile online. You can visit kupos.cl or download our app and buy your tickets in the easiest and most convenient way for you, using cash, debit or credit card, PayPal, etc. You can also buy your tickets directly on the bus company's website.
The cheapest bus ticket from Santiago to Uyuni costs CLP$ , and is available on August 15, 2026 at kupos.cl.
offers the cheapest bus ticket from Santiago to Uyuni, in a seat for CLP $ , to travel on August 15, 2026 at kupos.cl.
The distance between Santiago and Uyuni is 0 Kms, and the bus trip can take a minimum of 00 hours.
The earliest departure to travel by bus from Santiago to Uyuni is at and is offered by
The latest departure to travel by bus from Santiago to Uyuni is at and is offered by .
According to reviews and ratings from kupos.cl users, the three best companies for travelling by bus from Santiago to Uyuni are:
On buses from Santiago to Uyuni
Generally, buses travelling from Santiago to Uyuni have the following features and amenities: phone charger, WiFi, air conditioning, television, coffee, among others.
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